Hunter Clark will make his first senior appearance of the season tomorrow night, with the classy midfielder one of four new faces for the landmark Spud's Game fixture.

Clark will be joined by the returning Jack Billings and Nasiah Wanganeen-Milera, while Ryan Byrnes has come into the starting 22 after spending his past four matches as the unused medical sub.

An AC injury sustained in the AAMI Community Series back in March put a stopper to the early part of Clark's 2022 campaign, with his subsequent three VFL appearances yielding an average of 28 disposals per game.

The incoming quartet replace injured pair Daniel McKenzie and Mitch Owens, omitted duo Mason Wood and Marcus Windhager and last week's medical sub Jarrod Lienert.

Windhager, Wood, Darragh Joyce and Cooper Sharman have been named as emergencies.

Spud's Game: Time 2 Talk marks one of the most significant days on the AFL calendar, with the prime-time fixture not only honouring the late Danny 'Spud' Frawley, but helping initiate all-important conversations to destigmatise mental health.

Supporters and attendees can purchase a virtual football in the lead-up to and during the game, with proceeds raising funds for mental health and suicide prevention programs delivered through the Danny Frawley Centre for Health and Wellbeing.

The start to the game will again be delayed by two minutes, with St Kilda Legend Nathan Burke and Essendon great and former Saints coach Tim Watson to address both playing groups in the centre square prior to the opening bounce.

St Kilda and Essendon will come together under the Friday night lights on 17 June for Spud's Game, with the opening bounce set for 7:52pm AEST.

IN: Billings, Byrnes, Clark, Wanganeen-Milera
OUT: Lienert (medi-sub), McKenzie (injured), Owens (injured), Windhager (omitted), Wood (omitted)