Fresh off their stirring debut, Peta Searle's women will head west to take on reigning Premiers, Adelaide.

The Saints will be forced to make one change following Nadia von Bertouch's season-ending knee injury last Sunday, with the South Australian missing out on a hometown outing.

Kelly O'Neill (omitted) and Emma Mackie (injured) will also make way in Round 2, opening the door for five potential debutants.

Former Magpie Darcy Guttridge, young talent Isabella Shannon and loyal Saint Alison Drennan could cover the Saints' midfield losses, while Courteney Munn and Poppy Kelly could provide a tall attacking option.

Shannon, Drennan, Munn and Kelly have been named on the extended bench.

Check back into saints.com.au at 4pm this Friday to view the final team of 21.

IN: Guttridge, Shannon, Drennan, Munn, Kelly
OUT: O'Neill (omitted), Mackie (injured), von Bertouch (injured)