Max King and Zak Jones will return to the senior line-up ahead of the landmark Spud's Game: Time 2 Talk in honour of the late Danny Frawley.
The pair were sidelined for the Saints' season opener with concussion and a hamstring injury respectively, but have ticked all the right boxes in time to face the Demons.
Jack Bytel (omitted) and Daniel McKenzie (omitted) have been squeezed out of the starting line-up ahead of King and Jones' return.
Bytel and McKenzie have been named as emergencies, alongside Jake Carlisle and Mason Wood.
Saturday night will mark a return to Marvel Stadium for St Kilda's first home game for Premiership Points in almost 600 days.
An official tribute to the late Danny 'Spud' Frawley, featuring some of St Kilda's greatest players as well as Danny’s family and friends, will begin at 7.00pm sharp.
St Kilda will square off with Melbourne in the inaugural Spud's Game: Time 2 Talk on Saturday 27 March, with the opening bounce pencilled in for 7:25pm.
IN: Jones, King
OUT: Bytel (omitted), McKenzie (omitted)
| B | Jimmy Webster | Dougal Howard | Callum Wilkie |
| HB | Ben Long | Tom Highmore | Jack Sinclair |
| C | Jack Billings | Sebastian Ross | Hunter Clark |
| HF | Dan Butler | Bradley Hill | Jack Lonie |
| F | Tim Membrey | Shaun McKernan | Max King |
| R | Paul Hunter | Jack Steele | Jade Gresham |
| INT | Jack Higgins | Zak Jones | Josh Battle |
| Nick Coffield | |||
| E | Jack Bytel | Daniel McKenzie | Jake Carlisle |
| Mason Wood |
